The PLAG1 antibody from Wuhan Fine Biotech Co., Ltd. is a Rabbit Polyclonal antibody to PLAG1, and PLAG1 zinc finger. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The PLAG1 antibody has been validated for the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia